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ClassicsinTotalSynthesisIII

ClassicsinTotalSynthesisIII

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作者: K. C. Nicolaou 著 , Jason S. Chen 著

出版社: Wiley-VCH

出版时间: 2011-04

ISBN: 9783527329588

定价: 1139.00

装帧: 精装

页数: 770页

正文语种: 英语

分类: 外文古旧书>英文书>自然科学

Retaining his excellent, proven approach, world-famous chemist and passionate teacher K.C. Nicolaou and his student Jason S. Chen compile here the important strategies and tools employed to construct complex molecules. Through 42 syntheses of 25 challenging natural products they explain they key steps of the synthetic pathway, highlighting the major developments for easier understanding, and contrasting these to other synthetic methods. Similar to its predecessors and completing a trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions. In contrast to the first two volumes, this new one features full-color frontispieces . A wonderful tool for learning and teaching, and a must-have for all current and future organic, medicinal and biological chemists. From the reviews: “The present volume—and hopefully future books of this series—offer an exciting and outstanding overview of the subject of natural products total syntheses in its complexity and variety. Classics in Total Synthesis III will surely itself become a classic in the literature on the state of the art of contemporary organic synthetic chemistry.“ - Angewandte Chemie Int. Ed. 2011 "... a volume, (...) which any chemist with an interest in synthetic organic chemistry will wish to acquire." -JACS (on a previous volume) "...this superb book (...) will be an essential purchase for many organic chemists." -Nature (on a previous volume) "... One of my co-workers confessed that Classics I was the book on his bedside table while he prepared his thesis defense. Isn't that the highest distinction for a monograph?" -Angewandte Chemie, 2004 (on a previous volume) K. C. Nicolaou is Professor of Chemistry at the University of California, San Diego and is Chairman of the Department of Chemistry and holds the Skaggs Professorship of Chemical Biology and the Darlene Shiley Chair in Chemistry at The Scripps Research Insitute. He studied chemistry at the University of London, and finished his Ph.D. in 1972 with Professors Sondheimer and Garratt. After his postdocs at Columbia University with Professor Katz and Harvard University with Professor Corey, he joined the University of Pennsylvania, before accepting appointments at the University of California in San Diego. His impact on chemistry flows from his works in chemical synthesis and chemical biology described in over 550 publications and 55 patents, and he received numereous awards from all over the world. His book "Classics in Total Synthesis I and II" are long- and bestsellers as well as undispensible in view of chemical education in the strategy of organic synthesis. Jason S. Chen received his AB and AM degrees in 2001 from Harvard University, where he performed research in the group of Professor Matthew D. Shair. He then joined Enanta Pharmaceuticals (USA) as a medicinal chemist studying novel cyclosporine analogs. He joined K.C. Nicolaou's group at the Scripps Research Institute in 2003. In 2008, he completed his Ph.D. on the total synthesis and biological evaluation of uncialamycin. He is working currently as a research associate in K.C. Nicolaous laboratory.
内容简介:
Retaining his excellent, proven approach, world-famous chemist and passionate teacher K.C. Nicolaou and his student Jason S. Chen compile here the important strategies and tools employed to construct complex molecules. Through 42 syntheses of 25 challenging natural products they explain they key steps of the synthetic pathway, highlighting the major developments for easier understanding, and contrasting these to other synthetic methods. Similar to its predecessors and completing a trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality of the reactions. In contrast to the first two volumes, this new one features full-color frontispieces . A wonderful tool for learning and teaching, and a must-have for all current and future organic, medicinal and biological chemists. From the reviews: “The present volume—and hopefully future books of this series—offer an exciting and outstanding overview of the subject of natural products total syntheses in its complexity and variety. Classics in Total Synthesis III will surely itself become a classic in the literature on the state of the art of contemporary organic synthetic chemistry.“ - Angewandte Chemie Int. Ed. 2011 "... a volume, (...) which any chemist with an interest in synthetic organic chemistry will wish to acquire." -JACS (on a previous volume) "...this superb book (...) will be an essential purchase for many organic chemists." -Nature (on a previous volume) "... One of my co-workers confessed that Classics I was the book on his bedside table while he prepared his thesis defense. Isn't that the highest distinction for a monograph?" -Angewandte Chemie, 2004 (on a previous volume)
作者简介:
K. C. Nicolaou is Professor of Chemistry at the University of California, San Diego and is Chairman of the Department of Chemistry and holds the Skaggs Professorship of Chemical Biology and the Darlene Shiley Chair in Chemistry at The Scripps Research Insitute. He studied chemistry at the University of London, and finished his Ph.D. in 1972 with Professors Sondheimer and Garratt. After his postdocs at Columbia University with Professor Katz and Harvard University with Professor Corey, he joined the University of Pennsylvania, before accepting appointments at the University of California in San Diego. His impact on chemistry flows from his works in chemical synthesis and chemical biology described in over 550 publications and 55 patents, and he received numereous awards from all over the world. His book "Classics in Total Synthesis I and II" are long- and bestsellers as well as undispensible in view of chemical education in the strategy of organic synthesis. Jason S. Chen received his AB and AM degrees in 2001 from Harvard University, where he performed research in the group of Professor Matthew D. Shair. He then joined Enanta Pharmaceuticals (USA) as a medicinal chemist studying novel cyclosporine analogs. He joined K.C. Nicolaou's group at the Scripps Research Institute in 2003. In 2008, he completed his Ph.D. on the total synthesis and biological evaluation of uncialamycin. He is working currently as a research associate in K.C. Nicolaous laboratory.

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