国外优秀生命科学教学用书：基础分子生物学（影印版）
出版时间:
2008-06
版次:
1
ISBN:
9787040250572
定价:
69.00
装帧:
平装
开本:
16开
纸张:
胶版纸
页数:
725页
字数:
950千字
正文语种:
英语
27人买过
-
Thebeginningsofmolecularbiology,ThestructureofDNA,Genomeorganization：fromnucleotidestochromatin,TheversatilityofRNA,Fromgenetoprotein,DNAreplicationandtelomeremaintenance,DNArepairandrecombination,RecombinantDNAtechnologyandmolecularcloning。 1Thebeginningsofmolecularbiology
1.1Introduction
1.2Historicalperspective
Insightsintoheredityfromroundandwrinkledpeas:Mendeliangenetics
InsightsintothenatureofhereditarymateriaL:thetransformingprincipleisDNA
Creativityinapproachleadstotheonegene-oneenzymehypothesis
Theimportanceoftechnologicaladvances:theHershey-Chaseexperiment
AmodelforthestructureofDNA:theDNAdoublehelix
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
2ThestructureofDNA
2.1Introduction
2.2Primarystructure:thecomponentsofnucleicacids
Five-carbonsugars
Nitrogenousbases
Thephosphatefunctionalgroup
Nucleosidesandnucteotides
2.3Significanceof5and3
2.4Nomenclatureofnucleotides
2.5ThelengthofRNAandDNA
2.6SecondarystructureofDNA
Hydrogenbondsformbetweenthebases
BasestackingprovideschemicalstabilitytotheDNAdoublehelix
StructureoftheWatson-CrickDNAdoublehelix
Distinguishingbetweenfeaturesofalternativedouble-helicalstructures
DNAcanundergoreversiblestrandseparation
2.7UnusualDNAsecondarystructures
Slippedstructures
Cruciformstructures
TriplehelixDNA
Diseasebox2.1FriedreichsataxiaandtriplehelixDNA
2.8TertiarystructureofDNA
SupercoilingofDNA
TopoisomerasesrelaxsupercoiledDNA
Whatisthesignificanceofsupercoitinginvivo?
Diseasebox2.2Topoisomerase-targetedanticancerdrugs
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
3Genomeorganization:fromnucleotidestochromatin
3.1Introduction
3.2Eukaryoticgenome
Chromatinstructure：historicalperspective
Histones
Nucleosomes
Beads-on-a-string：the10nmfiber
The30nmfiber
Loopdomains
Metaphasechromosomes
Alternativechromatinstructures
3.3Bacterialgenome
3.4Plasmids
3.5BacteriophagesandmammalianDNAviruses
Bacteriophaqes
MammalianDNAViruses
3.6Organellegenomes：chloroplastsandmitochondria
ChloroplastDNA(cpDNA)
MitochondrialDNA(mtDNA)
Diseasebox3.1MitochondrialDNAanddisease
3.7RNA-basedgenomes
EukaryoticRNAviruses
Retroviruses
Viroids
OtherSubviralpathoqens
Diseasebox3.2Avianflu
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
4TheversatilityofRNA
4.1Introduction
4.2SecondarystructureofRNA
SecondarystructuremotifsinRNA
Base-pairedRNAadoptsanA-typedoublehelix
RNAhelicesoftencontainnoncanonicalbasepairs
4.3TertiarystructureofRNA
tRNAstructure：importantinsiqhtsintoRNAstructuralmotifs
CommontertiarystructuremotifsinRNA
4.4KineticsofRNAfolding
4.5RNAisinvolvedinawiderangeofcellularprocesses
4.6Historicalperspective：thediscoveryofRNAcatalysis
TetrahymenaqroUPIintronribozyme
RNasePribozyme
Focusbox4.1：TheRNAWorld
4.7Ribozymescatalyzeavarietyofchemicalreactions
Modeofribozymeaction
Largeribozymes
Smallribozymes
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
5Fromgenetoprotein
5.1Introduction
5.2Thecentraldogma
5.3Thegeneticcode
Translatingthegeneticcode
The21stand22ndgeneticallyencodedaminoacids
Roleofmodifiednucleotidesindecoding
Implicationsofcodonbiasformolecularbiologists
5.4Proteinstructure
Primarystructure
Secondarystructure
Tertiarystructure
Quaternarystructure
Sizeandcomplexityofproteins
Proteinscontainmultiplefunctionaldomains
Predictionofproteinstructure
5.5Proteinfunction
Enzymesarebiologicalcatalysts
Regulationofproteinactivitybypost-translationalmodifications
Allostericregulationofproteinactivity
Cyclin-dependentkinaseactivation
Macromolecularassemblages
5.6Proteinfoldingandmisfolding
MoLecularchaperones
Ubiquitin-mediatedproteindegradation
Proteinmisfoldingdiseases
Diseasebox5.1Prions
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
6DNAreplicationandtelomeremaintenance
6.1Introduction
6.2Historicalperspective
InsightintothemodeofDNAreplication:theMeselson-Stahlexperiment
InsightintothemodeofDNAreplication:visualizationofreplicatingbacterialDNA
6.3DNAsynthesisoccursfrom5→3
6.4DNApolymerasesaretheenzymesthatcatalyzeDNAsynthesis
Focusbox6.1BacterialDNApolymerases
6.5SemidiscontinuousDNAreplication
Leadingstrandsynthesisiscontinuous
Laggingstrandsynthesisisdiscontinuous
6.6NuclearDNAreplicationineukaryoticcells
Replicationfactories
Histoneremovalattheoriginsofreplication
Prereplicationcomplexformationattheoriginsofreplication
ReplicationLicensing:DNAonlyreplicatesoncepercellcycle
Duplexunwindingatreplicationforks
RNAprimingofLeadingstrandandLaggingstrandDNAsynthesis
Polymeraseswitching
ElongationofLeadingstrandsandLaggingstrands
Proofreading
MaturationofnascentDNAstrands
Termination
Histonedeposition
Focusbox6.2ThenamingofgenesinvolvedinDNAreplication
Diseasebox6.1SystemiclupuserythematosusandPCNA
6.7ReplicationoforganelleDNA
ModelsformtDNAreplication
ReplicationofcpDNA
Diseasebox6.2RNaseMRPandcartilage-hairhypoplasia
6.8Rollingcirclereplication
6.9Tetomeremaintenance:theroleoftetomeraseinDNAreplication,aging,andcancer
Telomeres
Solutiontotheendreplicationproblem
Maintenanceoftelomeresbytelomerase
Othermodesoftelomeremaintenance
Regulationoftelomeraseactivity
Telomerase,aging,andcancer
Diseasebox6.3Dyskeratosiscongenita:lossoftelomerasefunction
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
7DNArepairandrecombination
7.1Introduction
7.2Typesofmutationsandtheirphenotypicconsequences
Transitionsandtransversionscanleadtosilent,missense,ornonsensemutations
Insertionsordeletionscancauseframeshiftmutations
Expansionoftrinucleotiderepeatsleadstogeneticinstability
7.3GeneralclassesofDNAdamage
Singlebasechanges
Structuraldistortion
DNAbackbonedamage
CellularresponsetoDNAdamage
7.4Lesionbypass
7.5DirectreversalofDNAdamage
7.6RepairofsinglebasechangesandstructuraldistortionsbyremovalofDNAdamage
Baseexcisionrepair
Mismatchrepair
Nucleotideexcisionrepair
Diseasebox7.1Hereditarynonpolyposiscolorectalcancer:adefectinmismatchrepair
7.7Double-strandbreakrepairbyremovalofDNAdamage
Homologousrecombination
Nonhomologousend-joining
Diseasebox7.2Xerodermapigmentosumandrelateddisorders:defectsinnucleotideexcisionrepair
Diseasebox7.3Hereditarybreastcancersyndromes:mutationsinBRCA1andBRCA2
8RecombinantDNAtechnologyandmolecularcloning
9Toolsforanalyzinggeneexpression
10Transcriptioninprokaryotes
11Transcriptionineukaryotes
12Epigeneticandmonoallelicgeneexpression
13RNAprocessingandpost-transcriptionalgeneregulation
14Themechanismoftranslation
15Geneticallymodifiedorganisms:useinbasicandappliedresearch
16Genomeanalysis:DNAtyping,genomicsandbeyond
17Medicalmolecularbiology
Glossary
Index
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内容简介:
Thebeginningsofmolecularbiology,ThestructureofDNA,Genomeorganization：fromnucleotidestochromatin,TheversatilityofRNA,Fromgenetoprotein,DNAreplicationandtelomeremaintenance,DNArepairandrecombination,RecombinantDNAtechnologyandmolecularcloning。
-
目录:
1Thebeginningsofmolecularbiology
1.1Introduction
1.2Historicalperspective
Insightsintoheredityfromroundandwrinkledpeas:Mendeliangenetics
InsightsintothenatureofhereditarymateriaL:thetransformingprincipleisDNA
Creativityinapproachleadstotheonegene-oneenzymehypothesis
Theimportanceoftechnologicaladvances:theHershey-Chaseexperiment
AmodelforthestructureofDNA:theDNAdoublehelix
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
2ThestructureofDNA
2.1Introduction
2.2Primarystructure:thecomponentsofnucleicacids
Five-carbonsugars
Nitrogenousbases
Thephosphatefunctionalgroup
Nucleosidesandnucteotides
2.3Significanceof5and3
2.4Nomenclatureofnucleotides
2.5ThelengthofRNAandDNA
2.6SecondarystructureofDNA
Hydrogenbondsformbetweenthebases
BasestackingprovideschemicalstabilitytotheDNAdoublehelix
StructureoftheWatson-CrickDNAdoublehelix
Distinguishingbetweenfeaturesofalternativedouble-helicalstructures
DNAcanundergoreversiblestrandseparation
2.7UnusualDNAsecondarystructures
Slippedstructures
Cruciformstructures
TriplehelixDNA
Diseasebox2.1FriedreichsataxiaandtriplehelixDNA
2.8TertiarystructureofDNA
SupercoilingofDNA
TopoisomerasesrelaxsupercoiledDNA
Whatisthesignificanceofsupercoitinginvivo?
Diseasebox2.2Topoisomerase-targetedanticancerdrugs
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
3Genomeorganization:fromnucleotidestochromatin
3.1Introduction
3.2Eukaryoticgenome
Chromatinstructure：historicalperspective
Histones
Nucleosomes
Beads-on-a-string：the10nmfiber
The30nmfiber
Loopdomains
Metaphasechromosomes
Alternativechromatinstructures
3.3Bacterialgenome
3.4Plasmids
3.5BacteriophagesandmammalianDNAviruses
Bacteriophaqes
MammalianDNAViruses
3.6Organellegenomes：chloroplastsandmitochondria
ChloroplastDNA(cpDNA)
MitochondrialDNA(mtDNA)
Diseasebox3.1MitochondrialDNAanddisease
3.7RNA-basedgenomes
EukaryoticRNAviruses
Retroviruses
Viroids
OtherSubviralpathoqens
Diseasebox3.2Avianflu
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
4TheversatilityofRNA
4.1Introduction
4.2SecondarystructureofRNA
SecondarystructuremotifsinRNA
Base-pairedRNAadoptsanA-typedoublehelix
RNAhelicesoftencontainnoncanonicalbasepairs
4.3TertiarystructureofRNA
tRNAstructure：importantinsiqhtsintoRNAstructuralmotifs
CommontertiarystructuremotifsinRNA
4.4KineticsofRNAfolding
4.5RNAisinvolvedinawiderangeofcellularprocesses
4.6Historicalperspective：thediscoveryofRNAcatalysis
TetrahymenaqroUPIintronribozyme
RNasePribozyme
Focusbox4.1：TheRNAWorld
4.7Ribozymescatalyzeavarietyofchemicalreactions
Modeofribozymeaction
Largeribozymes
Smallribozymes
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
5Fromgenetoprotein
5.1Introduction
5.2Thecentraldogma
5.3Thegeneticcode
Translatingthegeneticcode
The21stand22ndgeneticallyencodedaminoacids
Roleofmodifiednucleotidesindecoding
Implicationsofcodonbiasformolecularbiologists
5.4Proteinstructure
Primarystructure
Secondarystructure
Tertiarystructure
Quaternarystructure
Sizeandcomplexityofproteins
Proteinscontainmultiplefunctionaldomains
Predictionofproteinstructure
5.5Proteinfunction
Enzymesarebiologicalcatalysts
Regulationofproteinactivitybypost-translationalmodifications
Allostericregulationofproteinactivity
Cyclin-dependentkinaseactivation
Macromolecularassemblages
5.6Proteinfoldingandmisfolding
MoLecularchaperones
Ubiquitin-mediatedproteindegradation
Proteinmisfoldingdiseases
Diseasebox5.1Prions
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
6DNAreplicationandtelomeremaintenance
6.1Introduction
6.2Historicalperspective
InsightintothemodeofDNAreplication:theMeselson-Stahlexperiment
InsightintothemodeofDNAreplication:visualizationofreplicatingbacterialDNA
6.3DNAsynthesisoccursfrom5→3
6.4DNApolymerasesaretheenzymesthatcatalyzeDNAsynthesis
Focusbox6.1BacterialDNApolymerases
6.5SemidiscontinuousDNAreplication
Leadingstrandsynthesisiscontinuous
Laggingstrandsynthesisisdiscontinuous
6.6NuclearDNAreplicationineukaryoticcells
Replicationfactories
Histoneremovalattheoriginsofreplication
Prereplicationcomplexformationattheoriginsofreplication
ReplicationLicensing:DNAonlyreplicatesoncepercellcycle
Duplexunwindingatreplicationforks
RNAprimingofLeadingstrandandLaggingstrandDNAsynthesis
Polymeraseswitching
ElongationofLeadingstrandsandLaggingstrands
Proofreading
MaturationofnascentDNAstrands
Termination
Histonedeposition
Focusbox6.2ThenamingofgenesinvolvedinDNAreplication
Diseasebox6.1SystemiclupuserythematosusandPCNA
6.7ReplicationoforganelleDNA
ModelsformtDNAreplication
ReplicationofcpDNA
Diseasebox6.2RNaseMRPandcartilage-hairhypoplasia
6.8Rollingcirclereplication
6.9Tetomeremaintenance:theroleoftetomeraseinDNAreplication,aging,andcancer
Telomeres
Solutiontotheendreplicationproblem
Maintenanceoftelomeresbytelomerase
Othermodesoftelomeremaintenance
Regulationoftelomeraseactivity
Telomerase,aging,andcancer
Diseasebox6.3Dyskeratosiscongenita:lossoftelomerasefunction
Chaptersummary
Analyticalquestions
Suggestionsforfurtherreading
7DNArepairandrecombination
7.1Introduction
7.2Typesofmutationsandtheirphenotypicconsequences
Transitionsandtransversionscanleadtosilent,missense,ornonsensemutations
Insertionsordeletionscancauseframeshiftmutations
Expansionoftrinucleotiderepeatsleadstogeneticinstability
7.3GeneralclassesofDNAdamage
Singlebasechanges
Structuraldistortion
DNAbackbonedamage
CellularresponsetoDNAdamage
7.4Lesionbypass
7.5DirectreversalofDNAdamage
7.6RepairofsinglebasechangesandstructuraldistortionsbyremovalofDNAdamage
Baseexcisionrepair
Mismatchrepair
Nucleotideexcisionrepair
Diseasebox7.1Hereditarynonpolyposiscolorectalcancer:adefectinmismatchrepair
7.7Double-strandbreakrepairbyremovalofDNAdamage
Homologousrecombination
Nonhomologousend-joining
Diseasebox7.2Xerodermapigmentosumandrelateddisorders:defectsinnucleotideexcisionrepair
Diseasebox7.3Hereditarybreastcancersyndromes:mutationsinBRCA1andBRCA2
8RecombinantDNAtechnologyandmolecularcloning
9Toolsforanalyzinggeneexpression
10Transcriptioninprokaryotes
11Transcriptionineukaryotes
12Epigeneticandmonoallelicgeneexpression
13RNAprocessingandpost-transcriptionalgeneregulation
14Themechanismoftranslation
15Geneticallymodifiedorganisms:useinbasicandappliedresearch
16Genomeanalysis:DNAtyping,genomicsandbeyond
17Medicalmolecularbiology
Glossary
Index
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基础分子生物学
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